Endocrine Abstracts

Background: MTC tends to metastasize early in the course of the disease affecting usually regional lymph nodes; in 7–23% of patients distant metastases may be present at diagnosis (common metastatic sites:liver, lungs, bone). We present two MTC cases with unusual metastases to the breast, pancreas and mandible.Case presentation: Patient No 1: a 48-year-old female was diagnosed with MTC in 1990. Total thyroidectomy was performed followed by neck diss...

Background: MTC tends to metastasize early in the course of the disease affecting usually regional lymph nodes; in 7–23% of patients distant metastases may be present at diagnosis (common metastatic sites:liver, lungs, bone). We present two MTC cases with unusual metastases to the breast, pancreas and mandible.Case presentation: Patient No 1A 48-year-old female was diagnosed with MTC in 1990. Total thyroidectomy was performed...

Introduction: Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumor of the gastrointestinal tract that consists of a dual adenocarcinomatous and neuroendocrine differentiation. The clinical behavior seems to be influenced by the neuroendocrine component. We report a patient with mixed adenoneuroendocrine carcinoma of cecum who presented 18 years after her initial diagnosis and treatment.Case report: A 59-year-old woman presented with a 3-month hist...

Introduction: In 30–50% of cases central diabetes insipidus (CDI) is idiopathic. Other causes include tumours, pituitary surgery, cranial trauma or infiltrative diseases. Long-term medical follow-up is crucial given that idiopathic CDI can be the earliest sign of an evolving process (inflammatory or tumoural).Case report: We report the case of a 23-year-old woman who presented with isolated polydipsia and polyuria. The diagnosis of isolated CDI was ...

Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common feature of type 2 diabetes mellitus (T2DM). Liver fibrosis has been associated with an increased risk of cardiovascular diseases (CVD).Aim: To investigate whether the fibrosis 4 index (FIB-4), a non-invasive marker of liver fibrosis, is associated with CVD or cancer in patients with T2DM.Methods: Two hundred and nine consecutive T2DM patients...

Background: While the association between cigarette smoking and type 2 diabetes is established, the impact of smoking on developing gestational diabetes mellitus (GDM) remains controversial.Aim: To investigate whether maternal cigarette smoking during pregnancy is a risk factor for developing GDM.Methods: MEDLINE, Scopus, CENTRAL and Google Scholar databases were searched from inception to December 2022 to identify eligible origina...

Aim: Autoimmune thyroid disease (AITD) is the most common adverse effect in alemtuzumab (ALZ) treated relapsing–remitting (RR) multiple sclerosis (MS) patients. The objective of this prospective study was to analyze the occurrence, timing of onset, clinical course, and laboratory characteristics of AITD post-ALZ and subsequently the clinical outcome of AITD post-ALZ in patients who received ocrelizumab.Patients and methods: We evaluated 36 RRMS pati...